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\u9f3b\u54bd\u764c\u662f\u4e00\u7a2e\u539f\u767c\u65bc\u9f3b\u54bd\u90e8\u9ecf\u819c\u4e0a\u76ae\u7684\u60e1\u6027\u816b\u7624\uff0c\u662f\u5e38\u898b\u7684\u982d\u9838\u90e8\u816b\u7624\u4e4b\u4e00\u3002\u64da\u7d71\u8a08\uff0c2020\u5e74\u5168\u7403\u9f3b\u54bd\u764c\u65b0\u767c\u75c5\u4f8b\u6578\u8d85\u904e13\u842c^{[1]<\/sup>\uff0c\u5176\u4e2d\u8fd1\u534a\u6578\u75c5\u4f8b\u5728\u4e2d\u570b^{[2]<\/sup>\u3002\u4e2d\u570b\u5357\u65b9\uff08\u5982\u5ee3\u6771\u3001\u5ee3\u897f\uff09\u548c\u6771\u5357\u4e9e\u5730\u5340\u9ad8\u767c^{[3]<\/sup>\u3002\u5c0d\u65bc\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\uff0c\u76ee\u524d\u7684\u6cbb\u7642\u624b\u6bb5\u6709\u9650\uff0c\u4e00\u7dda\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u662f\u4ee5\u9251\u985e\u70ba\u57fa\u790e\u7684\u5169\u85e5\u806f\u5408\u5316\u7642\uff0c\u4f46\u6cbb\u7642\u5f8c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u6642\u9593\u50c5\u67097\u500b\u6708\u5de6\u53f3^{[4]<\/sup>\u3002<\/p>\n\n\n\n}}}}

\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u5f90\u745e\u83ef\u6559\u6388\u5718\u968a\u8207\u672c\u571f\u5275\u65b0\u85e5\u4f01\u541b\u5be6\u751f\u7269\u5408\u4f5c\uff0c\u81ea2016\u5e74\u8d77\u63a2\u7d22\u65b0\u8208\u514d\u75ab\u7642\u6cd5\u8207\u50b3\u7d71\u5316\u7642\u76f8\u7d50\u5408\u7684\u5275\u65b0\u578b\u81e8\u5e8a\u65b9\u6848\uff0c\u958b\u5c55\u5f8c\u7dda\u81f3\u4e00\u7dda\u6cbb\u7642\u201c\u5168\u7dda\u8cab\u7a7f\u201d\u7684\u81e8\u5e8a\u4f48\u5c40\u3002\u5f9eIb\/II\u671f\u7684\u5c0f\u6a23\u672c\u91cf\u63a2\u7d22\u6027\u7814\u7a76\u3001II\u671f\u514d\u75ab\u55ae\u85e5\u4e8c\u7dda\u53ca\u5f8c\u7dda\u6cbb\u7642\u7684POLARIS-02\u7814\u7a76\uff0c\u518d\u5230\u9996\u5275\u5168\u7403\u898f\u6a21\u6700\u5927\u7684\u570b\u969b\u591a\u4e2d\u5fc3\u201c\u514d\u75ab\u6cbb\u7642+\u5316\u7642\u201d\u4e00\u7dda\u6cbb\u7642\u7684JUPITER-02\u7814\u7a76\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\uff08\u62d3\u76ca^{\u00ae<\/sup>\uff09\u5728\u9f3b\u54bd\u764c\u6cbb\u7642\u9818\u57df\u53d6\u5f97\u4e86\u624e\u5be6\u7684\u5faa\u8b49\u91ab\u5b78\u8b49\u64da\u3002<\/p>\n\n\n\n}

\u6b64\u6b21\u65b0\u9069\u61c9\u75c7\u7684\u7372\u6279\u57fa\u65bcJUPITER-02\u7814\u7a76\uff08NCT03581786\uff09\uff0c\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u570b\u969b\u591a\u4e2d\u5fc3III\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u7531\u5f90\u745e\u83ef\u6559\u6388<\/strong>\u64d4\u4efb\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u5169\u5730\u540c\u6642\u8a3b\u518a\u3002\u81ea2018\u5e7411\u6708\u81f32019\u5e7410\u6708\uff0cJUPITER-02\u7814\u7a76\u5728\u4e2d\u570b\u5927\u9678\u3001\u4e2d\u570b\u81fa\u7063\u3001\u65b0\u52a0\u5761\u768435\u5bb6\u7814\u7a76\u4e2d\u5fc3\u5171\u7d0d\u5165289\u4f8b\u672a\u63a5\u53d7\u904e\u5316\u7642\u7684\u5fa9\u767c\/\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u3002<\/p>\n\n\n\n

\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u8207\u55ae\u7d14\u5316\u7642\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5409\u897f\u4ed6\u6ff1\u548c\u9806\u9251\uff08GP\u5316\u7642\uff09\u4e00\u7dda\u6cbb\u7642\u5fa9\u767c\/\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u53ef\u7372\u5f97\u66f4\u512a\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u66f4\u9ad8\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u548c\u66f4\u9577\u7684\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08DoR\uff09\uff0c\u5b89\u5168\u6027\u53ef\u7ba1\u7406\uff0c\u4e14\u7121\u8ad6\u60a3\u8005PD-L1\u8868\u9054\u5982\u4f55\uff0c\u5747\u53ef\u7372\u76ca\u3002\u622a\u81f3\u671f\u4e2d\u5206\u6790\u65e5\uff082020\u5e745\u670830\u65e5\uff09\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u7d44\u7684\u4e2d\u4f4dPFS\u9054\u523011.7\u500b\u6708\uff0c\u6bd4\u5b89\u6170\u5291\u806f\u5408\u5316\u7642\u7d44\u5ef6\u95773.7\u500b\u6708\uff08HR=0.52 [95\uff05CI\uff1a0.36-0.74]\uff0c\u96d9\u5074p=0.0003\uff09\uff1b\u5c07\u8fd1\u4e00\u534a\u60a3\u8005\u8d85\u904e\u4e00\u5e74\u9084\u6c92\u6709\u767c\u751f\u75be\u75c5\u9032\u5c55\uff0c\u6bd4\u5b89\u6170\u5291\u7d44\u591a21.5%\uff0c\u4ee3\u8868\u6709\u66f4\u591a\u60a3\u8005\u7372\u76ca\uff1bORR\u70ba77.4% vs 66.4%\uff08P=0.033\uff09\uff0c\u4e2d\u4f4dDoR\u70ba10.0 vs 5.7\u500b\u6708\uff08HR = 0.50 [95\uff05CI\uff1a0.33-0.78]\uff09\uff0c\u6bd4\u5b89\u6170\u5291\u7d44\u5ef6\u9577\u8fd11\u500d\uff1b\u76ee\u524d\u4e2d\u4f4d\u7e3d\u751f\u5b58\uff08OS\uff09\u4ecd\u672a\u6210\u719f\uff0c\u4e0d\u904e\u5df2\u89c0\u5bdf\u5230\u7279\u745e\u666e\u5229\u55ae\u6297\u7d44\u7e3d\u751f\u5b58\u7684\u7372\u76ca\u8da8\u52e2\uff0c\u5176\u6b7b\u4ea1\u98a8\u96aa\u964d\u4f4e\u4e8640%\u3002<\/p>\n\n\n\n

\u4f5c\u70ba\u8fc4\u4eca\u70ba\u6b62\u5168\u7403\u7bc4\u570d\u5167\u898f\u6a21\u6700\u5927\u7684\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u806f\u5408\u5316\u7642\u4e00\u7dda\u6cbb\u7642\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff0cJUPITER-02\u7814\u7a76\u591a\u6b21\u7372\u5f97\u570b\u969b\u5b78\u754c\u9ad8\u5ea6\u95dc\u6ce8\uff0c\u66fe\u4ee5\u201c\u91cd\u78c5\u7814\u7a76\u6458\u8981\u201d\u5f62\u5f0f\uff08#LBA2\uff09\u5165\u9078\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u5e74\u6703\uff08ASCO 2021\uff09\u5168\u9ad4\u5927\u6703\uff0c\u4e26\u57282021\u5e749\u6708\u4ee5\u5c01\u9762\u63a8\u85a6\u5f62\u5f0f\u520a\u767b\u5728SCI\u5f71\u97ff\u56e0\u6578\u6392\u540d\u524d20\u4f4d\u7684\u570b\u969b\u9802\u5c16\u671f\u520a\u300a\u81ea\u7136-\u91ab\u5b78\u300b\u96dc\u8a8c\uff08Nature Medicine<\/em>\uff0c\u5f71\u97ff\u56e0\u6578\uff1a53.440\uff09\uff0c\u9019\u4e5f\u662f\u300a\u81ea\u7136-\u91ab\u5b78\u300b\u5275\u520a26\u5e74\u4f86\u9996\u6b21\u5728\u5c01\u9762\u4e0a\u63a8\u85a6\u4e2d\u570b\u5275\u65b0\u85e5\u7269\u7814\u7a76\u3002<\/p>\n\n\n\n

\u57fa\u65bc\u7279\u745e\u666e\u5229\u55ae\u6297\u5728POLARIS-02\u548cJUPITER-02\u5169\u9805\u7814\u7a76\u4e2d\u53d6\u5f97\u7684\u5353\u8d8a\u6210\u679c\uff0c\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u8a72\u85e5\u54c12\u9805\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\uff0c\u65e8\u5728\u52a0\u901f\u5176\u958b\u767c\u548c\u5be9\u8a55\u7a0b\u5f0f\u3002\u76ee\u524d\uff0c\u541b\u5be6\u751f\u7269\u5df2\u5411FDA\u63d0\u4ea4\u4e86\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5409\u897f\u4ed6\u6ff1\/\u9806\u9251\u4f5c\u70ba\u665a\u671f\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\u548c\u55ae\u85e5\u7528\u4e8e\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u542b\u9251\u6cbb\u7642\u5f8c\u7684\u4e8c\u7dda\u53ca\u4ee5\u4e0a\u6cbb\u7642\u7684\u5169\u9805\u9069\u61c9\u75c7\u7684\u751f\u7269\u88fd\u54c1\u8a31\u53ef\u7533\u8acb\uff08BLA\uff09\u4e26\u7372\u53d7\u7406\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u4e5f\u662f\u9996\u500b\u5411FDA\u63d0\u4ea4BLA\u7684\u570b\u7522\u6297PD-1\u55ae\u6297\u3002<\/p>\n\n\n\n

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<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e\uff1a<\/h5>\n\n\n\n
[1]<\/a> https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/4-Nasopharynx-fact-sheet.pdf.<\/h5>\n\n\n\n
[2]<\/a> https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf.<\/h5>\n\n\n\n
[3]<\/a> Chen YP, et al. Lancet 2019.394:64-80,<\/h5>\n\n\n\n
[4]<\/a> https:\/\/ascopubs.org\/doi\/abs\/10.1200\/JCO.2020.38.15_suppl.6521.<\/h5>\n\n\n\n\n\n
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