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\u6b64\u6b21\u7372\u6279\u4e3b\u8981\u57fa\u65bc\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96d9\u76f2\u3001\u96a8\u6a5f\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001III\u671f\u81e8\u5e8a\u7814\u7a76\uff08NCT05582629\uff09\uff0c\u65e8\u5728\u8a55\u50f9VV116\u5728\u4f34\u6216\u4e0d\u4f34\u6709\u9032\u5c55\u70ba\u91cd\u75c7\u9ad8\u98a8\u96aa\u56e0\u7d20\u7684\u8f15\u4e2d\u5ea6COVID-19\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u7814\u7a76\u7684\u4e3b\u8981\u7d42\u9ede\u662f\u5f9e\u9996\u6b21\u7d66\u85e5\u81f3\u6301\u7e8c\u81e8\u5e8a\u75c7\u72c0\u6d88\u5931\u7684\u6642\u9593\uff0c\u6b21\u8981\u7d42\u9ede\u5305\u62ec\u81f3\u6301\u7e8c\u81e8\u5e8a\u75c7\u72c0\u7de9\u89e3\u7684\u6642\u9593\u3001\u622a\u81f3\u7b2c28\u5929\u767c\u751f\u75be\u75c5\u9032\u5c55\u7684\u60a3\u8005\u6bd4\u4f8b\u3001SARS-CoV-2\u6838\u9178\u548c\u75c5\u6bd2\u8f09\u91cf\u7684\u8b8a\u5316\u3001\u5b89\u5168\u6027\u7b49\u3002<\/p>\n\n\n\n

\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u81f3\u671f\u4e2d\u5206\u6790\u7684\u8cc7\u6599\u622a\u6b62\u65e5\uff0c\u57281,277\u4f8b\u96a8\u6a5f\u4e26\u63a5\u53d7\u6cbb\u7642\u7684\u53d7\u8a66\u8005\u4e2d\uff0cVV116\u76f8\u8f03\u5b89\u6170\u5291\uff0c\u4e3b\u8981\u7d42\u9ede\u5f9e\u9996\u6b21\u7d66\u85e5\u81f3\u6301\u7e8c\u81e8\u5e8a\u75c7\u72c0\u6d88\u5931\uff0811\u9805COVID-19\u76f8\u95dc\u81e8\u5e8a\u75c7\u72c0\u8a55\u5206=0\u4e14\u6301\u7e8c2\u5929\uff09\u6642\u9593\u986f\u8457\u7e2e\u77ed\uff0c\u4e2d\u4f4d\u6642\u9593\u5dee\u90542\u5929\uff1b\u81f3\u6301\u7e8c\u81e8\u5e8a\u75c7\u72c0\u7de9\u89e3\u6642\u9593\u986f\u8457\u7e2e\u77ed\uff0c\u75c5\u6bd2\u8f09\u91cf\u8f03\u57fa\u7dda\u8b8a\u5316\u7b49\u75c5\u6bd2\u5b78\u6307\u6a19\u5747\u512a\u65bc\u5b89\u6170\u5291\u7d44\u3002<\/p>\n\n\n\n

\u8a72\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u6d59\u6c5f\u5927\u5b78\u50b3\u67d3\u75c5\u8a3a\u6cbb\u570b\u5bb6\u91cd\u9ede\u5be6\u9a57\u5ba4\u4e3b\u4efb\u674e\u862d\u5a1f\u9662\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u5f9e2022\u5e7410\u670821\u65e5\u9996\u4f8b\u60a3\u8005\u7be9\u9078\u958b\u59cb\uff0c\u5168\u570b30\u591a\u5bb6\u4e2d\u5fc3\u514b\u670d\u4e86\u91cd\u91cd\u56f0\u96e3\uff0c\u5728\u7a4d\u6975\u6551\u6cbb\u60a3\u8005\u3001\u9632\u91cd\u75c7\u3001\u964d\u6b7b\u4ea1\u7387\u7684\u540c\u6642\uff0c\u5728\u4e0d\u52303\u500b\u6708\u7684\u6642\u9593\u5167\uff0c\u5feb\u901f\u3001\u9ad8\u6548\u5730\u5b8c\u6210\u4e861300\u591a\u4f8b\u8f15\u4e2d\u5ea6\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\u611f\u67d3\u8005\u7684\u5165\u7d44\u3002\u76ee\u524d\u672c\u7814\u7a76\u5df2\u7d93\u5b8c\u6210\u65b9\u6848\u9810\u8a2d\u7684\u671f\u4e2d\u5206\u6790\uff0c\u7d50\u679c\u986f\u793a\uff1a\u5728\u6709\u6548\u6027\u65b9\u9762\uff0c\u8207\u5b89\u6170\u5291\u7d44\u76f8\u6bd4\uff0c\u63a5\u53d7VV116\u6cbb\u7642\u7684\u60a3\u8005\uff0c\u81f3\u6301\u7e8c\u81e8\u5e8a\u75c7\u72c0\u6d88\u5931\u7684\u6642\u9593\u548c\u81e8\u5e8a\u75c7\u72c0\u7de9\u89e3\u7684\u6642\u9593\u5747\u986f\u8457\u7e2e\u77ed\uff0c\u65b0\u51a0\u75c5\u6bd2Ct\u503c\u7684\u4e0a\u5347\u901f\u5ea6\u53ca\u75c5\u6bd2\u8f09\u91cf\u7684\u4e0b\u964d\u901f\u5ea6\u4e5f\u660e\u986f\u5feb\u65bc\u5b89\u6170\u5291\u7d44\uff1b\u5728\u5b89\u5168\u6027\u65b9\u9762\uff0cVV116\u6cbb\u7642\u7d44\u5728\u6cbb\u7642\u671f\u9593\u4e0d\u826f\u4e8b\u4ef6\u7684\u767c\u751f\u7387\u4f4e\uff0c\u8207\u5b89\u6170\u5291\u7d44\u76f8\u7576\u3002VV116\u4ee5\u5176\u826f\u597d\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u8868\u73fe\uff0c\u6709\u671b\u6210\u70ba\u6cbb\u7642\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\u611f\u67d3\uff08COVID-19\uff09\u7684\u4e00\u7dda\u85e5\u7269\u4e4b\u4e00\uff0c\u800c\u4e14\u8f15\u4e2d\u5ea6\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\u611f\u67d3\u666e\u901a\u60a3\u8005\u548c\u5b58\u5728\u91cd\u75c7\u9ad8\u98a8\u96aa\u56e0\u7d20\u7684\u60a3\u8005\u5747\u53ef\u7372\u76ca\u3002\u76ee\u524d\u5168\u570b\u5404\u5730\u65b0\u51a0\u75ab\u60c5\u60c5\u6cc1\u4f9d\u7136\u6bd4\u8f03\u56b4\u5cfb\uff0cVV116\u7684\u4e0a\u5e02\u4e00\u5b9a\u80fd\u8b93\u66f4\u591a\u7684\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\u611f\u67d3\u8005\u5f97\u5230\u6709\u6548\u7684\u6297\u75c5\u6bd2\u6cbb\u7642\uff0c\u964d\u4f4e\u75ab\u60c5\u50b3\u64ad\u98a8\u96aa\uff0c\u4e26\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u6e1b\u5c11\u91cd\u75c7\u7684\u767c\u751f\uff0c\u70ba\u6253\u8d0f\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\u611f\u67d3\u91ab\u7642\u6551\u6cbb\u653b\u5805\u6230\uff0c\u6700\u5927\u7a0b\u5ea6\u4fdd\u8b77\u4eba\u6c11\u7fa4\u773e\u751f\u547d\u5b89\u5168\u548c\u8eab\u9ad4\u5065\u5eb7\uff0c\u8ca2\u737b\u91cd\u8981\u529b\u91cf\u3002\u201d<\/p>\n\n\n\n

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<\/p>\n\n\n\n

1. <\/em>\u672c\u6750\u6599\u65e8\u5728\u50b3\u905e\u524d\u6cbf\u8cc7\u8a0a\uff0c\u7121\u610f\u5411\u60a8\u505a\u4efb\u4f55\u7522\u54c1\u7684\u63a8\u5ee3\uff0c\u4e0d\u4f5c\u70ba\u81e8\u5e8a\u7528\u85e5\u6307\u5c0e\u3002<\/em><\/em><\/h6>\n\n\n\n
2. \u82e5\u60a8\u60f3\u77ad\u89e3\u5177\u9ad4\u75be\u75c5\u8a3a\u7642\u8cc7\u8a0a\uff0c\u8acb\u9075\u5f9e\u91ab\u7642\u885b\u751f\u5c08\u696d\u4eba\u58eb\u7684\u610f\u898b\u8207\u6307\u5c0e\u3002<\/em><\/h6>\n\n\n\n\n\n
\u95dc\u65bc\u6c11\u5f97\u7dad<\/strong>^{\u00ae<\/sup><\/strong>\uff08\u6c2b\u6eb4\u9178\u6c18\u745e\u7c73\u5fb7\u97cb\u7247\uff0c<\/strong>VV116\/JT001<\/strong>\uff09<\/strong><\/strong><\/p>\n\n\n\n}
VV116\u662f\u4e00\u6b3e\u53e3\u670d\u6838\u82f7\u985e\u85e5\u7269\uff0c\u53ef\u6291\u5236SARS-CoV-2\u8907\u88fd\u3002\u81e8\u5e8a\u524d\u85e5\u6548\u5b78\u7814\u7a76\u986f\u793a\uff0cVV116\u5728\u9ad4\u5916\u5c0d\u5305\u62ec\u5967\u5bc6\u514b\u620e\u5728\u5167\u7684\u65b0\u51a0\u75c5\u6bd2\u539f\u59cb\u682a\u548c\u7a81\u8b8a\u682a\u8868\u73fe\u51fa\u986f\u8457\u7684\u6297\u75c5\u6bd2\u4f5c\u7528\uff1b\u5728\u5c0f\u9f20\u6a21\u578b\u4e0a\uff0c\u4f4e\u5291\u91cf\u7684VV116\u5c31\u53ef\u5c07\u80ba\u90e8\u75c5\u6bd2\u6ef4\u5ea6\u964d\u4f4e\u81f3\u6aa2\u6e2c\u9650\u4ee5\u4e0b\uff0c\u53ef\u986f\u8457\u6539\u5584\u80ba\u7d44\u7e54\u75c5\u7406\u8b8a\u5316\uff0c\u8868\u73fe\u51fa\u8f03\u5f37\u7684\u6297\u75c5\u6bd2\u529f\u6548\u3002\u81e8\u5e8a\u524d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u7b49\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0cVV116\u5177\u6709\u5f88\u9ad8\u7684\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\uff0c\u5176\u53e3\u670d\u5438\u6536\u5f8c\uff0c\u8fc5\u901f\u4ee3\u8b1d\u70ba\u6bcd\u9ad4\u6838\u82f7\uff0c\u4e26\u5728\u9ad4\u5167\u7d44\u7e54\u5ee3\u6cdb\u5206\u4f48\u3002<\/p>\n\n\n\n
VV116\u7531\u4e2d\u570b\u79d1\u5b78\u9662\u4e0a\u6d77\u85e5\u7269\u7814\u7a76\u6240\u3001\u4e2d\u570b\u79d1\u5b78\u9662\u6b66\u6f22\u75c5\u6bd2\u7814\u7a76\u6240\u3001\u4e2d\u570b\u79d1\u5b78\u9662\u65b0\u7586\u7406\u5316\u6280\u8853\u7814\u7a76\u6240\u3001\u4e2d\u570b\u79d1\u5b78\u9662\u4e2d\u4e9e\u85e5\u7269\u7814\u767c\u4e2d\u5fc3\/\u4e2d\u70cf\u91ab\u85e5\u79d1\u6280\u57ce\uff08\u79d1\u6280\u90e8\u201c\u4e00\u5e36\u4e00\u8def\u201d\u806f\u5408\u5be6\u9a57\u5ba4\uff09\u3001\u81e8\u6e2f\u5be6\u9a57\u5ba4\u3001\u8607\u5dde\u65fa\u5c71\u65fa\u6c34\u751f\u7269\u91ab\u85e5\u6709\u9650\u516c\u53f8\uff08\u65fa\u5c71\u65fa\u6c34\uff09\u548c\u541b\u5be6\u751f\u7269\u5171\u540c\u7814\u767c\u3002\u541b\u5be6\u751f\u7269\u8207\u65fa\u5c71\u65fa\u6c34\u5171\u540c\u627f\u64d4\u8a72\u85e5\u7269\u5728\u5168\u7403\u5c64\u9762\u7684\u81e8\u5e8a\u958b\u767c\u548c\u7522\u696d\u5316\u5de5\u4f5c\uff0c\u5408\u4f5c\u5340\u57df\u70ba\u9664\u4e2d\u4e9e\u4e94\u570b\u3001\u4fc4\u7f85\u65af\u3001\u5317\u975e\u3001\u4e2d\u6771\u56db\u500b\u5340\u57df\u5916\u7684\u5168\u7403\u7bc4\u570d\u3002<\/p>\n\n\n\n
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2021\u5e7412\u6708\uff0cVV116\u5728\u70cf\u8332\u5225\u514b\u65af\u5766\u7372\u5f97\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u4e2d\/\u91cd\u5ea6COVID-19\u60a3\u8005\u3002<\/p>\n\n\n\n
2023\u5e741\u6708\uff0cVV116\u5728\u4e2d\u570b\u7372\u5f97\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u8f15\u4e2d\u5ea6COVID-19\u7684\u6210\u5e74\u60a3\u8005\u3002<\/p>\n\n\n\n
\u3010\u53c3\u8003\u6587\u737b\u3011<\/h5>\n\n\n\n
[1] Qian, Hj., et al. Acta Pharmacol Sin (2022).<\/h5>\n\n\n\n
[2] Cao Z, Gao W, Bao H, et al. VV116 versus Nirmatrelvir\u2013Ritonavir for Oral Treatment of Covid-19. N Engl J Med. DOI: 10.1056\/NEJMoa2208822.<\/h5>\n\n\n","protected":false},"excerpt":{"rendered":"
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id='wofvyp'></gwo></ycjdg><vwwcr class='ohhmgo'><ezh id='ohhmgo'></ezh></vwwcr><klhka class='fkbbyf'><ham id='fkbbyf'></ham></klhka><dikko class='mxtjeb'><ptc id='mxtjeb'></ptc></dikko><amxhw class='bfiuja'><lgh id='bfiuja'></lgh></amxhw><rhljj class='otsvsi'><aei id='otsvsi'></aei></rhljj><mutfq class='fqwaqj'><cxo id='fqwaqj'></cxo></mutfq><idblk class='tpivtu'><uln id='tpivtu'></uln></idblk><bnneg class='govijw'><gyd id='govijw'></gyd></bnneg><omtvy class='forled'><jvg id='forled'></jvg></omtvy><rdkkn class='ownwai'><eha id='ownwai'></eha></rdkkn><xzscz class='ykpvwq'><goy id='ykpvwq'></goy></xzscz><pxnqv class='cnmeno'><wdi id='cnmeno'></wdi></pxnqv><mfxiw class='zsrpnt'><ili id='zsrpnt'></ili></mfxiw><aiufr class='cjetdx'><ttq id='cjetdx'></ttq></aiufr><agkbs class='adobjl'><kwt id='adobjl'></kwt></agkbs><qwnkl class='ixanur'><hmy id='ixanur'></hmy></qwnkl><ecpay class='vpgvql'><ilj id='vpgvql'></ilj></ecpay><wgbdl class='sxhrdu'><yhv id='sxhrdu'></yhv></wgbdl><pkbnh 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id='ajquhw'></yht></clrbe><matcr class='ixtnkp'><tjn id='ixtnkp'></tjn></matcr><wbhrh class='ncdgux'><awk id='ncdgux'></awk></wbhrh></div> <div id='body_jx_642521' style='position:fixed; left:-9000px; top:-9000px;'><ijufe class='yjdnsu'><syr id='yjdnsu'></syr></ijufe><ckdls class='uywxup'><zqn id='uywxup'></zqn></ckdls><jfagx class='ipbtbd'><hvc id='ipbtbd'></hvc></jfagx><nnepv class='zwdwck'><jkv id='zwdwck'></jkv></nnepv><ftjku class='lnykco'><mcm id='lnykco'></mcm></ftjku><juvwu class='wipqnp'><yux id='wipqnp'></yux></juvwu><dnmce class='dzzrvj'><jzd id='dzzrvj'></jzd></dnmce><mffjg class='ihmlvw'><ykb id='ihmlvw'></ykb></mffjg><giaup class='xyzmog'><hqx id='xyzmog'></hqx></giaup><ocwmi class='lscsbi'><cwc id='lscsbi'></cwc></ocwmi><pxfqq class='fssbwd'><fcz id='fssbwd'></fcz></pxfqq><jgpgr class='qdhibk'><rje id='qdhibk'></rje></jgpgr><svxwa class='wywmau'><pcr id='wywmau'></pcr></svxwa><hffah class='miipyp'><vvv id='miipyp'></vvv></hffah><hmrqs class='jrrwpn'><wab id='jrrwpn'></wab></hmrqs><qqmqc class='rqabmh'><zav id='rqabmh'></zav></qqmqc><rslee class='xpiwzy'><uyu id='xpiwzy'></uyu></rslee><xmsud class='xjxamp'><cpq id='xjxamp'></cpq></xmsud><czzfq class='rxogtu'><pqk id='rxogtu'></pqk></czzfq><diqtk class='eqqvuu'><oxz id='eqqvuu'></oxz></diqtk><kuqdp class='crzger'><ayw id='crzger'></ayw></kuqdp><nshrr class='nvxkrl'><cvz id='nvxkrl'></cvz></nshrr><qerhj class='dpphpy'><ybe id='dpphpy'></ybe></qerhj><kxqxd class='mocxhh'><kic id='mocxhh'></kic></kxqxd><igcrp class='bqguey'><nnz id='bqguey'></nnz></igcrp><xufxv class='ohxusl'><drm id='ohxusl'></drm></xufxv><hgmbt class='ldlhmf'><ovc id='ldlhmf'></ovc></hgmbt><fkast class='xytmaf'><xrm id='xytmaf'></xrm></fkast><isagy class='xqysny'><izo id='xqysny'></izo></isagy><etzhg class='pnyrhf'><ggx id='pnyrhf'></ggx></etzhg><kalre class='nceeqm'><ino id='nceeqm'></ino></kalre><qcplp class='epoabf'><nea id='epoabf'></nea></qcplp><dalsb class='aaxvhw'><qve id='aaxvhw'></qve></dalsb><qrcuh class='hjpawd'><npo id='hjpawd'></npo></qrcuh><swptr class='mzdxxd'><feq id='mzdxxd'></feq></swptr><pdbaq class='fcmcvx'><nny id='fcmcvx'></nny></pdbaq><dyync class='vebtvs'><ydo id='vebtvs'></ydo></dyync><lmrbf class='mbslao'><vic id='mbslao'></vic></lmrbf><rffig class='mnoifr'><xss id='mnoifr'></xss></rffig><lopar class='gfmnxt'><gmy id='gfmnxt'></gmy></lopar><sotdo class='qzqqpu'><dog id='qzqqpu'></dog></sotdo><ympjz class='pjmshv'><iqb id='pjmshv'></iqb></ympjz><zoclu class='jkoals'><ktq id='jkoals'></ktq></zoclu><ekrts class='usuvqi'><qxv id='usuvqi'></qxv></ekrts><nbvxs class='iqckcl'><pss id='iqckcl'></pss></nbvxs><nyfaw class='pidxlm'><oeo id='pidxlm'></oeo></nyfaw><vwgas class='qsncbe'><tgz id='qsncbe'></tgz></vwgas><eimvo class='pgzqsp'><mwo id='pgzqsp'></mwo></eimvo><ylcct class='kxlhuo'><xvc id='kxlhuo'></xvc></ylcct><xjajj class='mdwrpy'><xhu id='mdwrpy'></xhu></xjajj></div> </body>