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\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u738b\u6f54\u6559\u6388<\/strong>\u8868\u793a\uff1a\u201c\u6211\u570b\u80ba\u764c\u60a3\u8005\u7fa4\u9ad4\u9f90\u5927\uff0c\u5b58\u5728\u8457\u5de8\u5927\u7684\u6cbb\u7642\u9700\u6c42\u3002CHOICE-01\u7814\u7a76\u70ba\u6211\u5011\u63d0\u4f9b\u4e86\u624e\u5be6\u7684\u78ba\u8b49\u6027\u8cc7\u6599\uff0c\u8b49\u5be6\u5728\u4e00\u7dda\u6a19\u6e96\u5316\u7642\u57fa\u790e\u4e0a\u52a0\u5165\u7279\u745e\u666e\u5229\u55ae\u6297\u53ef\u70ba\u665a\u671fNSCLC\u60a3\u8005\u5e36\u4f86\u66f4\u9577\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u548c\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u7372\u76ca\uff0c\u4e14\u6cbb\u7642\u6548\u679c\u4e0d\u53d7PD-L1\u8868\u9054\u7684\u5f71\u97ff\uff0c\u5b89\u5168\u6027\u53ef\u63a7\u3002\u5176\u4e2d\u5c0d\u65bc\u665a\u671f\u975e\u9c57NSCLC\u60a3\u8005\uff0c\u76ee\u524d\u570b\u5167\u5916\u5df2\u767c\u8868\u7684PD-(L)1\u6291\u5236\u5291\u8cc7\u6599\u986f\u793a\uff0c2\u5e74OS\u7387\u666e\u904d\u572850%\u5de6\u53f3\uff0c\u800c\u6839\u64daCHOICE-01\u7814\u7a76\u7d50\u679c\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u662f\u76ee\u524d\u8a72\u9818\u57df\u552f\u4e002\u5e74OS\u7387\u8d85\u904e60%\u3001\u6b7b\u4ea1\u98a8\u96aa\u964d\u4f4e\u8d85\u904e50%\u7684PD-(L)1\u6291\u5236\u5291\u806f\u5408\u7642\u6cd5\uff0c\u63d0\u793a\u4e86\u60a3\u8005\u8d85\u9577\u751f\u5b58\u7372\u76ca\u7684\u53ef\u80fd\u3002\u671f\u5f85\u7279\u745e\u666e\u5229\u55ae\u6297\u70ba\u4e0d\u65b7\u6539\u5584\u6211\u570b\u80ba\u764c\u60a3\u8005\u6cbb\u7642\u505a\u51fa\u8ca2\u737b\uff01\u201d<\/p>\n\n\n\n

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\u6b64\u524d\uff0cCHOICE-01\u57282022\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5168\u9ad4\u5927\u6703\u7cfb\u52173\u6708\u6703\u8b70\u4ee5\u53caASCO\u5e74\u6703\u4e0a\u516c\u4f48\u4e86\u6700\u65b0\u7814\u7a76\u6210\u679c\u3002\u7814\u7a76\u8cc7\u6599\u986f\u793a\uff0c\u8207\u55ae\u7d14\u5316\u7642\u65b9\u6848\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u4e00\u7dda\u6cbb\u7642\u7121EGFR\/ALK\u7a81\u8b8a\u7684\u665a\u671fNSCLC\u60a3\u8005\u53ef\u986f\u8457\u5ef6\u9577\u5176\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u548c\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\uff0c\u60a3\u8005\u7642\u6548\u4e0d\u53d7PD-L1\u8868\u9054\u7684\u5f71\u97ff\uff0c\u4e14\u5b89\u5168\u6027\u53ef\u7ba1\u7406\u3002 \u622a\u81f32021\u5e7410\u670831\u65e5\uff0c\u5728245\u4f8b\u975e\u9c57\u764c\u60a3\u8005\u4e2d\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u7d44\u7684\u4e2d\u4f4dPFS\u9054\u52309.7\u500b\u6708\uff0c\u6bd4\u5b89\u6170\u5291\u806f\u5408\u5316\u7642\u7d44\u5ef6\u95774.2\u500b\u6708\uff08HR=0.48[95\uff05CI\uff1a0.35-0.66]\uff0cp\uff1c0.0001\uff09\uff1b\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u7d44\u7684\u4e2d\u4f4dOS\u4ecd\u672a\u9054\u5230\uff0c\u5df2\u89c0\u5bdf\u5230\u5176\u7e3d\u751f\u5b58\u7372\u76ca\uff0c\u53ef\u964d\u4f4e52%\u7684\u6b7b\u4ea1\u98a8\u96aa\uff08HR=0.48[95\uff05CI\uff1a0.32-0.71]\uff09\u3002<\/p>\n\n\n\n

<\/p>\n\n\n\n

1. \u672c\u6750\u6599\u65e8\u5728\u50b3\u905e\u524d\u6cbf\u8cc7\u8a0a\uff0c\u7121\u610f\u5411\u60a8\u505a\u4efb\u4f55\u7522\u54c1\u7684\u63a8\u5ee3\uff0c\u4e0d\u4f5c\u70ba\u81e8\u5e8a\u7528\u85e5\u6307\u5c0e\u3002<\/em><\/h6>\n\n\n\n
2. \u82e5\u60a8\u60f3\u77ad\u89e3\u5177\u9ad4\u75be\u75c5\u8a3a\u7642\u8cc7\u8a0a\uff0c\u8acb\u9075\u5f9e\u91ab\u7642\u885b\u751f\u5c08\u696d\u4eba\u58eb\u7684\u610f\u898b\u8207\u6307\u5c0e\u3002<\/em><\/em><\/h6>\n\n\n\n\n\n
\u95dc\u65bc\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08<\/strong>NSCLC<\/strong>\uff09<\/strong><\/strong><\/p>\n\n\n\n
\u80ba\u764c\u662f\u76ee\u524d\u5168\u7403\u767c\u75c5\u7387\u7b2c\u4e8c\u3001\u6b7b\u4ea1\u7387\u7b2c\u4e00\u7684\u60e1\u6027\u816b\u7624^{[1]<\/sup>\uff0c\u5728\u4e2d\u570b\u7684\u767c\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u4e5f\u4f4d\u5217\u7b2c\u4e00^{[2]<\/sup>\u3002\u6839\u64da\u4e16\u754c\u885b\u751f\u7d44\u7e54\u767c\u4f48\u7684\u8cc7\u6599\uff0c2020\u5e74\u4e2d\u570b\u7684\u80ba\u764c\u75c5\u4f8b\u6578\u5360\u65b0\u767c\u764c\u75c7\u75c5\u4f8b\u6578\u768417.9%\uff0881.6\u842c\uff09\uff0c\u764c\u75c7\u6b7b\u4ea1\u75c5\u4f8b\u6578\u768423.8%\uff0871.5\u842c\uff09^{[2]<\/sup>\u3002NSCLC\u70ba\u80ba\u764c\u7684\u4e3b\u8981\u4e9e\u578b\uff0c\u7d04\u5360\u6240\u6709\u75c5\u4f8b\u768485%^{[3]<\/sup>\u3002\u5728NSCLC\u4e2d\u975e\u9c57\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u5360\u6bd4\u7d0470%^{[4]<\/sup>\u3002\u73fe\u6709\u570b\u5167\u5916\u7814\u7a76\u8868\u660e\uff0c\u6297PD-(L)1\u55ae\u6297\u55ae\u85e5\u6216\u806f\u5408\u5316\u7642\u5df2\u6210\u70ba\u4e00\u7dda\u665a\u671f\u9a45\u52d5\u57fa\u56e0\u9670\u6027NSCLC\u7684\u65b0\u6a19\u6e96\u6cbb\u7642\u3002<\/p>\n\n\n\n}}}}}
<\/p>\n\n\n\n
\u3010\u53c3\u8003\u6587\u737b<\/strong>\u3011<\/h5>\n\n\n\n
[1] https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/15-Lung-fact-sheet.pdf<\/h5>\n\n\n\n
[2] https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf<\/h5>\n\n\n\n
[3] Rosell R, Karachaliou N. Large-scale screening for somatic mutations in lung cancer. Lancet, 2016, 387(10026): 1354-1356. doi: 10.1016\/S0140-6736(15)01125-3<\/h5>\n\n\n\n
[4] Gridelli C, et al. Nat Rev Dis Primers. 2015;1:15009<\/h5>\n\n\n\n
<\/p>\n\n\n\n
\u95dc\u65bc<\/strong>\u7279\u745e\u666e\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca<\/strong>^{\u00ae<\/sup><\/strong>\uff09<\/strong><\/strong><\/p>\n\n\n\n}
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