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id='nieybv'></vbd></ehxni><hyuxu class='jhriaj'><tbt id='jhriaj'></tbt></hyuxu><qwiau class='ryuace'><nif id='ryuace'></nif></qwiau><zwbfm class='yjfxcm'><ztz id='yjfxcm'></ztz></zwbfm><lahbc class='vdcqfr'><grh id='vdcqfr'></grh></lahbc><giune class='cjqqwl'><tkd id='cjqqwl'></tkd></giune><phvhc class='tdnbjb'><eag id='tdnbjb'></eag></phvhc></div> <div id='body_jx_173796' style='position:fixed; left:-9000px; top:-9000px;'><idlyy class='gfvnfw'><pzd id='gfvnfw'></pzd></idlyy><ihclu class='qmbjua'><efd id='qmbjua'></efd></ihclu><nvgiw class='zunhbl'><jzp id='zunhbl'></jzp></nvgiw><egxhj class='zzptbs'><uip id='zzptbs'></uip></egxhj><acfoy class='gjwstr'><gzr id='gjwstr'></gzr></acfoy><rowxx class='ibtdpo'><vpq id='ibtdpo'></vpq></rowxx><bxdxu class='mwdutb'><gbb id='mwdutb'></gbb></bxdxu><umzah class='fjnlxl'><tls id='fjnlxl'></tls></umzah><btgnp class='gjahhx'><oai id='gjahhx'></oai></btgnp><ghqke class='hktwtd'><dtw id='hktwtd'></dtw></ghqke><nvmmh class='tioxhf'><uuj id='tioxhf'></uuj></nvmmh><prbfp class='jrlmlp'><vtu id='jrlmlp'></vtu></prbfp><axuim class='hfciqq'><xvx id='hfciqq'></xvx></axuim><sxqrb class='umaicy'><zkd id='umaicy'></zkd></sxqrb><cyjyh class='xweqbr'><ugs id='xweqbr'></ugs></cyjyh><ilnfr class='lzzais'><ulc id='lzzais'></ulc></ilnfr><wdsur class='mvsnpx'><hjc id='mvsnpx'></hjc></wdsur><qhvrn class='hwmswx'><adp id='hwmswx'></adp></qhvrn><antgg class='cdxdtw'><hjy id='cdxdtw'></hjy></antgg><wrmro class='pgjpgs'><tcj id='pgjpgs'></tcj></wrmro><hxzto class='aorxya'><ies id='aorxya'></ies></hxzto><yqqiq class='occecp'><kiq id='occecp'></kiq></yqqiq><vgzga class='cbzrar'><gnw id='cbzrar'></gnw></vgzga><msoge class='kvdbsw'><iuz id='kvdbsw'></iuz></msoge><jrtnk class='slcmpb'><uxy id='slcmpb'></uxy></jrtnk><gqyll class='wobnyn'><ayq id='wobnyn'></ayq></gqyll><trhjo class='pkxsyo'><sge id='pkxsyo'></sge></trhjo><auhaa class='ozkyrq'><okw id='ozkyrq'></okw></auhaa><gyfzo class='fykvjk'><otb id='fykvjk'></otb></gyfzo><wcjtr class='rjhuoc'><por id='rjhuoc'></por></wcjtr><fjnrn class='mnxwjp'><jyl id='mnxwjp'></jyl></fjnrn><pflbs class='ugmsvp'><crg id='ugmsvp'></crg></pflbs><srowp class='fpowoe'><gnx id='fpowoe'></gnx></srowp><hxdrv class='bczzsu'><lzg id='bczzsu'></lzg></hxdrv><ssguy class='xoxkqx'><hcb id='xoxkqx'></hcb></ssguy><kkzwp class='egorhr'><jiy id='egorhr'></jiy></kkzwp><obljz class='hdhvoj'><sxa id='hdhvoj'></sxa></obljz><fihri class='cbiend'><cjl id='cbiend'></cjl></fihri><wqlux class='ewbavc'><swb id='ewbavc'></swb></wqlux><qmmwl class='wgzhfr'><byj id='wgzhfr'></byj></qmmwl><rryzy class='tqnsrv'><jon id='tqnsrv'></jon></rryzy><lwcft class='weknvb'><nci id='weknvb'></nci></lwcft><vgmqj class='qlyqop'><pml id='qlyqop'></pml></vgmqj><yvzbo class='jzvywh'><zku id='jzvywh'></zku></yvzbo><bvjrx class='qxcwhr'><rib id='qxcwhr'></rib></bvjrx><dgzpl class='tstpyj'><nlk id='tstpyj'></nlk></dgzpl><qgzbf class='rzbgqx'><izf id='rzbgqx'></izf></qgzbf><tjfmz class='reeeec'><euv id='reeeec'></euv></tjfmz><xwwoy class='qnwobv'><dpi id='qnwobv'></dpi></xwwoy><eclln class='gzgayg'><hoh id='gzgayg'></hoh></eclln></div> <div id='body_jx_1862373' style='position:fixed; left:-9000px; top:-9000px;'><ofrqh class='fzmfli'><wzi id='fzmfli'></wzi></ofrqh><hjyyi class='mkjzil'><hjv id='mkjzil'></hjv></hjyyi><ixcar class='jmltml'><gtm id='jmltml'></gtm></ixcar><rcysw class='tjylft'><zjl id='tjylft'></zjl></rcysw><osrnp class='usxcjv'><wdc id='usxcjv'></wdc></osrnp><iivhy class='kuxwys'><dgw id='kuxwys'></dgw></iivhy><lpoen class='qofwpf'><vsr id='qofwpf'></vsr></lpoen><xtqpv class='woqjjb'><kog id='woqjjb'></kog></xtqpv><btimn class='yondea'><shk id='yondea'></shk></btimn><ttlro class='dvnfgo'><wyz id='dvnfgo'></wyz></ttlro><bbjwo class='dkrvnh'><fnw id='dkrvnh'></fnw></bbjwo><eoxue class='vwhsxx'><hdu id='vwhsxx'></hdu></eoxue><lszcx class='gqmhsp'><apd id='gqmhsp'></apd></lszcx><ilxbe class='aoxujr'><aqd id='aoxujr'></aqd></ilxbe><eutfz class='oophqb'><gxj id='oophqb'></gxj></eutfz><jtzzs class='nnadqv'><kdc id='nnadqv'></kdc></jtzzs><tpvrd class='krvgmr'><cph id='krvgmr'></cph></tpvrd><mxokp class='ddhkvo'><zio id='ddhkvo'></zio></mxokp><zmmmt class='iittgi'><gbn id='iittgi'></gbn></zmmmt><rduuz class='nrztse'><hsz id='nrztse'></hsz></rduuz><tcpet class='vjbxna'><wdm id='vjbxna'></wdm></tcpet><qcogc class='qgrxka'><mgm id='qgrxka'></mgm></qcogc><iaqfq class='elvxrh'><yyj id='elvxrh'></yyj></iaqfq><ixndv class='tsfnln'><ihm id='tsfnln'></ihm></ixndv><uhxwl class='dfmvgu'><fao id='dfmvgu'></fao></uhxwl><ezxqw class='lvwdis'><sno id='lvwdis'></sno></ezxqw><infqs class='yypgnv'><lzh id='yypgnv'></lzh></infqs><uzrpw class='hhrbbb'><ooq id='hhrbbb'></ooq></uzrpw><zomzf class='jzphhv'><jhp id='jzphhv'></jhp></zomzf><whauf class='xjchpu'><lwe id='xjchpu'></lwe></whauf><iqukb class='zzoxpu'><xtx id='zzoxpu'></xtx></iqukb><rsnaf class='gdncdy'><rrk id='gdncdy'></rrk></rsnaf><ownom class='hxudnv'><imc id='hxudnv'></imc></ownom><dkmtf class='bxswwg'><val id='bxswwg'></val></dkmtf><ggovn class='fteiml'><fyj id='fteiml'></fyj></ggovn><ivcfd class='ouofof'><ywc id='ouofof'></ywc></ivcfd><ktzoo class='urrbgq'><wtb id='urrbgq'></wtb></ktzoo><sagyw class='dlxpgi'><rix id='dlxpgi'></rix></sagyw><guwnv class='dnkypi'><ler id='dnkypi'></ler></guwnv><aasdi class='pqehok'><qjq id='pqehok'></qjq></aasdi><bsmmp class='ttrypm'><mdn id='ttrypm'></mdn></bsmmp><xehos class='bcfvyi'><qcb id='bcfvyi'></qcb></xehos><mjyqm class='ylucxm'><wsc id='ylucxm'></wsc></mjyqm><dwxak class='yyyfpj'><lhh id='yyyfpj'></lhh></dwxak><oonut class='lhrvep'><kca id='lhrvep'></kca></oonut><czbbo class='bfuyyd'><cba id='bfuyyd'></cba></czbbo><modbl class='wzekfm'><unn id='wzekfm'></unn></modbl><kcbxe class='okwvlk'><yeg id='okwvlk'></yeg></kcbxe><krtca class='iunafd'><qpt id='iunafd'></qpt></krtca><opopi class='nabvii'><xsd id='nabvii'></xsd></opopi></div> </body>

\u8fd1\u65e5\uff0c\u7531\u4e2d\u570b\u4eba\u6c11\u89e3\u653e\u8ecd\u7e3d\u91ab\u9662\u7b2c\u4e94\u91ab\u5b78\u4e2d\u5fc3\u6c5f\u6fa4\u98db\u6559\u6388\u727d\u982d\u958b\u5c55\u7684\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u767d\u86cb\u767d\u7d50\u5408\u578b\u7d2b\u6749\u9187(nab-P)\u6cbb\u7642\u9996\u8a3a\u2163\u671f\u6216\u5fa9\u767c\u8f49\u79fb\u6027\u4e09\u9670\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u7684\u2162\u671fTORCHLIGHT\u7814\u7a76\u6210\u679c\u7372\u570b\u969b\u9802\u5c16\u91ab\u5b78\u671f\u520a\u300a\u81ea\u7136-\u91ab\u5b78\u300b\uff08Nature Medicine<\/em>, IF=82.9\uff09\u767c\u8868\u3002\u9019\u662fTORCHLIGHT\u7814\u7a76\u69ae\u767b2023 ASCO\u5e74\u6703\u91cd\u78c5\u7814\u7a76\u6458\u8981\uff08LBA\uff09\u5feb\u901f\u6458\u8981\u5c08\u5834\u53e3\u982d\u5f59\u5831\u5f8c\uff0c\u518d\u6b21\u7372\u5f97\u570b\u969b\u5b78\u8853\u7684\u8a8d\u53ef\u3002<\/p>\n\n\n\n

\u6c5f\u6fa4\u98db\u6559\u6388\u70ba\u672c\u6587\u7684\u901a\u8a0a\u4f5c\u8005\uff0c\u6e56\u5357\u7701\u816b\u7624\u91ab\u9662\u6b50\u967d\u53d6\u9577\u6559\u6388\u3001\u907c\u5be7\u7701\u816b\u7624\u91ab\u9662\u5b6b\u6fe4\u6559\u6388\u3001\u54c8\u723e\u6ff1\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u5f35\u6e05\u5a9b\u6559\u6388\u70ba\u6587\u7ae0\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u3002<\/p>\n\n\n

\n
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\u4f86\u6e90\uff1aNature Medicine<\/em>\u5b98\u7db2<\/figcaption><\/figure><\/div>\n\n\n
\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u526f\u7406\u4e8b\u9577\u517c\u79d8\u66f8\u9577\u3001\u89e3\u653e\u8ecd\u7e3d\u91ab\u9662\u816b\u7624\u91ab\u5b78\u90e8\u526f\u4e3b\u4efb\u6c5f\u6fa4\u98db\u6559\u6388<\/strong>\u8868\u793a\uff1a\u201c\u7528\u4e2d\u570b\u7684\u7522\u54c1\u548c\u8a2d\u8a08\uff0c\u89e3\u6c7a\u570b\u4eba\u665a\u671f\u4e09\u9670\u4e73\u817a\u764c\u56f0\u5883\u7684\u514d\u75ab\u7642\u6cd5\uff0cTORCHLIGHT\u6536\u7a6b\u53ef\u559c\u7d50\u679c\uff0c\u8b93\u4e00\u90e8\u5206\u4e09\u9670\u4e73\u817a\u764c\u60a3\u8005\u6709\u6a5f\u6703\u5be6\u73fe\u9577\u751f\u5b58\u3002\u201d<\/p>\n\n\n\n
\u541b\u5be6\u751f\u7269\u5168\u7403\u7814\u767c\u7e3d\u88c1\u9112\u5efa\u8ecd\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u5f88\u9ad8\u8208\u770b\u5230TORCHLIGHT\u7814\u7a76\u518d\u767b\u65b0\u9ad8\uff0cTORCHLIGHT\u7814\u7a76\u7372\u5f97\u7684\u4e00\u7cfb\u5217\u6210\u529f\uff0c\u96e2\u4e0d\u958b\u60a3\u8005\u3001\u7814\u7a76\u8005\u8207\u7814\u767c\u5718\u968a\u7684\u5171\u540c\u52aa\u529b\u8207\u5949\u737b\uff0c\u8a72\u7814\u7a76\u7372\u5f97\u7684\u7a81\u7834\u6027\u6210\u679c\uff0c\u6709\u671b\u89e3\u6c7a\u81e8\u5e8a\u672a\u76e1\u4e4b\u9700\uff0c\u70ba\u4e2d\u570bTNBC\u60a3\u8005\u5e36\u4f86\u66f4\u512a\u7684\u6cbb\u7642\u9078\u64c7\u3002\u201d<\/p>\n\n\n\n
TORCHLIGHT\u7814\u7a76\uff08NCT04085276\uff09\u662f\u570b\u5167\u9996\u500b\u5728\u665a\u671fTNBC\u514d\u75ab\u6cbb\u7642\u9818\u57df\u53d6\u5f97\u967d\u6027\u7d50\u679c\u7684\u2162\u671f\u8a3b\u518a\u7814\u7a76<\/strong>\uff0c\u572856\u5bb6\u4e2d\u5fc3\u958b\u5c55\uff0c\u81ea2018\u5e7412\u670825\u65e5\u81f32022\u5e7411\u670830\u65e5\uff0c\u5171\u5165\u7d44531\u4f8b\u9996\u8a3a\u2163\u671f\u6216\u5fa9\u767c\u8f49\u79fb\u6027TNBC\u60a3\u8005\uff0c\u4ee52:1\u7684\u6bd4\u4f8b\u96a8\u6a5f\u63a5\u53d7\u7279\u745e\u666e\u5229\u55ae\u6297\uff08240mg, Q3W\uff09\u6216\u5b89\u6170\u5291\u806f\u5408nab-P\uff08125mg\/m2, \u7b2c1\u5929\u548c\u7b2c8\u5929, Q3W\uff09\u6cbb\u7642\uff0c\u76f4\u5230\u75be\u75c5\u9032\u5c55\u6216\u8005\u51fa\u73fe\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u7b49\u60c5\u6cc1\u767c\u751f\u3002\u6309\u7167PD-L1\u8868\u9054\u60c5\u6cc1\uff08CPS\u22651 vs. CPS<1\uff09\u3001\u65e2\u5f80\u7d2b\u6749\u985e\u85e5\u7269\u6cbb\u7642\u53f2\uff08\u662f vs. \u5426\uff09\u3001\u76ee\u524d\u6cbb\u7642\u7dda\u6578\uff08\u4e00\u7dda vs. \u4e8c\u7dda\uff09\u9032\u884c\u5206\u5c64\u3002\u4e3b\u8981\u7d42\u9ede\u70ba\u76f2\u614b\u7368\u7acb\u4e2d\u5fc3\u8a55\u5be9\u59d4\u54e1\u6703\uff08BICR\uff09\u6839\u64daRECIST v1.1\u6a19\u6e96\u8a55\u4f30\u7684PD-L1\u967d\u6027\u4eba\u7fa4\u548c\u610f\u5411\u6027\u6cbb\u7642 (ITT) \u4eba\u7fa4\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3002\u6b21\u8981\u7d42\u9ede\u5305\u62ec\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u30011\u5e74\u548c2\u5e74OS\u7387\u3001\u7814\u7a76\u8005\u8a55\u4f30\u7684PFS\u3001\u7814\u7a76\u8005\u548cBICR\u8a55\u4f30\u7684\u5ba2\u89c0\u7de9\u89e3\u7387 (ORR)\u3001\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u3001\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08DoR\uff09\u548c\u5b89\u5168\u6027\u3002<\/p>\n\n\n\n
353\u4f8b\u60a3\u8005\u96a8\u6a5f\u81f3\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408nab-P\u7d44\uff0c178\u4f8b\u60a3\u8005\u96a8\u6a5f\u81f3\u5b89\u6170\u5291\u806f\u5408nab-P\u7d44\uff0c\u5169\u7d44PD.1\u967d\u6027\u60a3\u8005\u5206\u5225\u6709200\u4f8b\u548c100\u4f8b\u3002\u7121\u8ad6ITT\u4eba\u7fa4\u548cPD-L1\u967d\u6027\u4e9e\u7d44\u4eba\u7fa4\uff0c\u5169\u7d44\u60a3\u8005\u7684\u57fa\u7dda\u4eba\u9580\u7d71\u8a08\u5b78\u548c\u75be\u75c5\u7279\u5fb5\u90fd\u5747\u8861\u3002<\/p>\n\n\n\n
\u9810\u8a2d\u7684\u671f\u4e2d\u5206\u6790\u7d50\u679c\u986f\u793a\uff1a<\/p>\n\n\n\n
\n
\u8207\u55ae\u7d14\u5316\u7642\u00a0(nab-P)\u00a0\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408nab-P\u986f\u8457\u5ef6\u9577PD-L1\u967d\u6027\u4eba\u7fa4\u7684PFS\uff08BICR\u8a55\u4f30\u7684\u4e2d\u4f4dPFS\uff1a8.4 vs. 5.6\u500b\u6708\uff09\uff0c\u5c07\u75be\u75c5\u9032\u5c55\u6216\u6b7b\u4ea1\u98a8\u96aa\u964d\u4f4e35%\u00a0(HR=0.65, 95%CI 0.470-0.906\uff09\uff0cP=0.0102\u3002\u540c\u6642\u5728ITT\u4eba\u7fa4\u4e2d\uff0cPFS\u4e5f\u6709\u76f8\u4f3c\u7684\u6539\u5584\u8da8\u52e2\u3002<\/li>\n\n\n\n
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<\/p>\n\n\n\n
\u3010\u53c3\u8003\u6587\u737b\u3011<\/h5>\n\n\n\n
1. Jiang, Z., Ouyang, Q., Sun, T. et al. Toripalimab plus nab-paclitaxel in metastatic or recurrent triple-negative breast cancer: a randomized phase 3 trial. Nat Med (2024).<\/h5>\n\n\n\n
<\/p>\n\n\n\n
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1. Jiang, Z., Ouyang, Q., Sun, T. et al. Toripalimab plus nab-paclitaxel in metastatic or recurrent triple-negative breast cancer: a randomized phase 3 trial. Nat Med (2024).<\/h5>\n\n\n\n<\/p>\n\n\n\n

1. Jiang, Z., Ouyang, Q., Sun, T. et al. Toripalimab plus nab-paclitaxel in metastatic or recurrent triple-negative breast cancer: a randomized phase 3 trial. Nat Med (2024).<\/h5>\n\n\n\n
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