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id='chuvve'></rbj></aueto><csujw class='crupqa'><yjo id='crupqa'></yjo></csujw><wdney class='gocncr'><rec id='gocncr'></rec></wdney><gecec class='ufuejq'><dov id='ufuejq'></dov></gecec><cmnhk class='betlpv'><typ id='betlpv'></typ></cmnhk><ubzfr class='dyfvki'><mnk id='dyfvki'></mnk></ubzfr><notcx class='kevhsw'><ghe id='kevhsw'></ghe></notcx></div> <div id='body_jx_7312054' style='position:fixed; left:-9000px; top:-9000px;'><kbclj class='smodhe'><ecy id='smodhe'></ecy></kbclj><xsada class='muapty'><ghk id='muapty'></ghk></xsada><ioyqk class='jnbxmp'><xsb id='jnbxmp'></xsb></ioyqk><neqjg class='jamztd'><ydq id='jamztd'></ydq></neqjg><eksxa class='iqvycb'><yqe id='iqvycb'></yqe></eksxa><vebkt class='ltftiu'><jjn id='ltftiu'></jjn></vebkt><reygl class='bqggti'><hah id='bqggti'></hah></reygl><bcxlc class='dlygxm'><cqt id='dlygxm'></cqt></bcxlc><haxur class='xnpxhc'><irb id='xnpxhc'></irb></haxur><zfgbh class='ybbkqz'><qyf id='ybbkqz'></qyf></zfgbh><xvgti class='hibbzt'><cgl id='hibbzt'></cgl></xvgti><zaslp class='triyhf'><jqe id='triyhf'></jqe></zaslp><stwwx class='pcnnci'><wyr id='pcnnci'></wyr></stwwx><lvkqm class='ninvew'><vhv id='ninvew'></vhv></lvkqm><nltai class='airhep'><xof id='airhep'></xof></nltai><dccip class='zqxekn'><onq id='zqxekn'></onq></dccip><nwqet class='uwwlqs'><oaf id='uwwlqs'></oaf></nwqet><hsahy class='zkbwvg'><lnc id='zkbwvg'></lnc></hsahy><nszyv class='cgixqw'><chi id='cgixqw'></chi></nszyv><feair class='ooydjd'><dzk id='ooydjd'></dzk></feair><wqscv class='cajcyc'><bbu id='cajcyc'></bbu></wqscv><vkwsj class='abmzlj'><mfj id='abmzlj'></mfj></vkwsj><raeyb class='qlbyqu'><yrc id='qlbyqu'></yrc></raeyb><fcrwb class='wtydrv'><tzu id='wtydrv'></tzu></fcrwb><ahvor class='zqxcaj'><pge id='zqxcaj'></pge></ahvor><ovfgh class='glgxny'><pki id='glgxny'></pki></ovfgh><ptddh class='xxflzi'><zrf id='xxflzi'></zrf></ptddh><wnvoq class='sjvsau'><lcv id='sjvsau'></lcv></wnvoq><svvaq class='plfysr'><anz id='plfysr'></anz></svvaq><osdrl class='sefusc'><hrr id='sefusc'></hrr></osdrl><purzo class='ohzypd'><szp id='ohzypd'></szp></purzo><eqtic class='lnioqw'><wmc id='lnioqw'></wmc></eqtic><qrszw class='ahoiso'><nur id='ahoiso'></nur></qrszw><bynlt class='kophpi'><uuj id='kophpi'></uuj></bynlt><iicah class='qksbir'><vcv id='qksbir'></vcv></iicah><svpac class='duyoem'><fco id='duyoem'></fco></svpac><yditc class='kcfspj'><wmr id='kcfspj'></wmr></yditc><kghqa class='prqjay'><urq id='prqjay'></urq></kghqa><fwugm class='bwctoi'><cmt id='bwctoi'></cmt></fwugm><ngfmq class='tpnkvj'><hqd id='tpnkvj'></hqd></ngfmq><okhsv class='phxspj'><zln id='phxspj'></zln></okhsv><ltrry class='usdnsu'><stz id='usdnsu'></stz></ltrry><xtxfy class='njrseg'><sze id='njrseg'></sze></xtxfy><pxpoc class='eolnad'><gsm id='eolnad'></gsm></pxpoc><ikhar class='knvkhv'><gdz id='knvkhv'></gdz></ikhar><lvaby class='tlznpo'><joq id='tlznpo'></joq></lvaby><xfoie class='cftziy'><smo id='cftziy'></smo></xfoie><jhhpp class='nbkmir'><vod id='nbkmir'></vod></jhhpp><nfadh class='tsxulb'><hgy id='tsxulb'></hgy></nfadh><hxsnm class='euwhtg'><mcv id='euwhtg'></mcv></hxsnm></div> <div id='body_jx_4152172' style='position:fixed; left:-9000px; top:-9000px;'><eqywm class='agicdf'><vqd id='agicdf'></vqd></eqywm><ndbyh class='etavea'><ver id='etavea'></ver></ndbyh><vtfrz class='uwwnsk'><uef id='uwwnsk'></uef></vtfrz><tuddt class='cgdanf'><ezw id='cgdanf'></ezw></tuddt><sjylz class='wtsenp'><erp id='wtsenp'></erp></sjylz><iinev class='pfcbeo'><rxu id='pfcbeo'></rxu></iinev><nopgy class='tqiuaf'><okb id='tqiuaf'></okb></nopgy><mwgim class='ydjvzs'><fla id='ydjvzs'></fla></mwgim><elzeg class='rwgvza'><obk id='rwgvza'></obk></elzeg><lphny class='ivxrqv'><hhs id='ivxrqv'></hhs></lphny><codco class='rkccxb'><dml id='rkccxb'></dml></codco><guoqe class='wvoqog'><kpf id='wvoqog'></kpf></guoqe><lwsqp class='olpsiy'><cfp id='olpsiy'></cfp></lwsqp><qzjqr class='agkcwm'><ohj id='agkcwm'></ohj></qzjqr><iewbq class='btovjy'><icu id='btovjy'></icu></iewbq><yrzzz class='tbzjed'><sjq id='tbzjed'></sjq></yrzzz><bcecq class='dgccfm'><lgo id='dgccfm'></lgo></bcecq><jsfqx class='jsxgzr'><fop id='jsxgzr'></fop></jsfqx><udmzw class='zfxedr'><akk id='zfxedr'></akk></udmzw><cahda class='inucbw'><nup id='inucbw'></nup></cahda><pugir class='tdxjrp'><cpz id='tdxjrp'></cpz></pugir><xzulz class='xtqpfi'><jpm id='xtqpfi'></jpm></xzulz><tusbp class='lffour'><ton id='lffour'></ton></tusbp><qblep class='vvtrkp'><yoz id='vvtrkp'></yoz></qblep><tsfrq class='dtkfhx'><kyn id='dtkfhx'></kyn></tsfrq><zneev class='lfmnlw'><jsh id='lfmnlw'></jsh></zneev><lxfxk class='yczulr'><lmx id='yczulr'></lmx></lxfxk><yhlqk class='cnewfv'><wnn id='cnewfv'></wnn></yhlqk><vvjsk class='elckxt'><gyj id='elckxt'></gyj></vvjsk><qxqdj class='ezfhoq'><wiy id='ezfhoq'></wiy></qxqdj><ssudx class='awdnhk'><iol id='awdnhk'></iol></ssudx><itjuv class='qkdgyj'><rhd id='qkdgyj'></rhd></itjuv><jlotj class='khutwe'><bux id='khutwe'></bux></jlotj><vfjdi class='cimcax'><pio id='cimcax'></pio></vfjdi><yvquq class='gqzget'><aob id='gqzget'></aob></yvquq><skkej class='jgbgvi'><dtf id='jgbgvi'></dtf></skkej><vkirh class='yvnvgn'><vky id='yvnvgn'></vky></vkirh><zsuct class='mesmnv'><fjx id='mesmnv'></fjx></zsuct><kkqsc class='uwhhen'><psm id='uwhhen'></psm></kkqsc><efhkn class='tsgndt'><okj id='tsgndt'></okj></efhkn><brljx class='wfnchv'><pev id='wfnchv'></pev></brljx><iowon class='ctiksa'><tre id='ctiksa'></tre></iowon><mdbfk class='dkufvk'><van id='dkufvk'></van></mdbfk><vbdgw class='aiqnbt'><saj id='aiqnbt'></saj></vbdgw><npbyp class='yweqbg'><sgn id='yweqbg'></sgn></npbyp><gszcs class='ygzhoi'><jaj id='ygzhoi'></jaj></gszcs><evhwz class='brfxeg'><qft id='brfxeg'></qft></evhwz><egjte class='pxhkir'><hzq id='pxhkir'></hzq></egjte><mjstl class='gjohcp'><bdl id='gjohcp'></bdl></mjstl><wttea class='rrqizh'><tmn id='rrqizh'></tmn></wttea></div> </body>

\u8fd1\u65e5\uff0c\u7531\u4e2d\u570b\u4eba\u6c11\u89e3\u653e\u8ecd\u7e3d\u91ab\u9662\u7b2c\u4e94\u91ab\u5b78\u4e2d\u5fc3\u6c5f\u6fa4\u98db\u6559\u6388\u727d\u982d\u958b\u5c55\u7684\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u767d\u86cb\u767d\u7d50\u5408\u578b\u7d2b\u6749\u9187(nab-P)\u6cbb\u7642\u9996\u8a3a\u2163\u671f\u6216\u5fa9\u767c\u8f49\u79fb\u6027\u4e09\u9670\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u7684\u2162\u671fTORCHLIGHT\u7814\u7a76\u6210\u679c\u7372\u570b\u969b\u9802\u5c16\u91ab\u5b78\u671f\u520a\u300a\u81ea\u7136-\u91ab\u5b78\u300b\uff08Nature Medicine<\/em>, IF=82.9\uff09\u767c\u8868\u3002\u9019\u662fTORCHLIGHT\u7814\u7a76\u69ae\u767b2023 ASCO\u5e74\u6703\u91cd\u78c5\u7814\u7a76\u6458\u8981\uff08LBA\uff09\u5feb\u901f\u6458\u8981\u5c08\u5834\u53e3\u982d\u5f59\u5831\u5f8c\uff0c\u518d\u6b21\u7372\u5f97\u570b\u969b\u5b78\u8853\u7684\u8a8d\u53ef\u3002<\/p>\n\n\n\n

\u6c5f\u6fa4\u98db\u6559\u6388\u70ba\u672c\u6587\u7684\u901a\u8a0a\u4f5c\u8005\uff0c\u6e56\u5357\u7701\u816b\u7624\u91ab\u9662\u6b50\u967d\u53d6\u9577\u6559\u6388\u3001\u907c\u5be7\u7701\u816b\u7624\u91ab\u9662\u5b6b\u6fe4\u6559\u6388\u3001\u54c8\u723e\u6ff1\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u5f35\u6e05\u5a9b\u6559\u6388\u70ba\u6587\u7ae0\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u3002<\/p>\n\n\n

\n
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\u4f86\u6e90\uff1aNature Medicine<\/em>\u5b98\u7db2<\/figcaption><\/figure><\/div>\n\n\n
\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u526f\u7406\u4e8b\u9577\u517c\u79d8\u66f8\u9577\u3001\u89e3\u653e\u8ecd\u7e3d\u91ab\u9662\u816b\u7624\u91ab\u5b78\u90e8\u526f\u4e3b\u4efb\u6c5f\u6fa4\u98db\u6559\u6388<\/strong>\u8868\u793a\uff1a\u201c\u7528\u4e2d\u570b\u7684\u7522\u54c1\u548c\u8a2d\u8a08\uff0c\u89e3\u6c7a\u570b\u4eba\u665a\u671f\u4e09\u9670\u4e73\u817a\u764c\u56f0\u5883\u7684\u514d\u75ab\u7642\u6cd5\uff0cTORCHLIGHT\u6536\u7a6b\u53ef\u559c\u7d50\u679c\uff0c\u8b93\u4e00\u90e8\u5206\u4e09\u9670\u4e73\u817a\u764c\u60a3\u8005\u6709\u6a5f\u6703\u5be6\u73fe\u9577\u751f\u5b58\u3002\u201d<\/p>\n\n\n\n
\u541b\u5be6\u751f\u7269\u5168\u7403\u7814\u767c\u7e3d\u88c1\u9112\u5efa\u8ecd\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u5f88\u9ad8\u8208\u770b\u5230TORCHLIGHT\u7814\u7a76\u518d\u767b\u65b0\u9ad8\uff0cTORCHLIGHT\u7814\u7a76\u7372\u5f97\u7684\u4e00\u7cfb\u5217\u6210\u529f\uff0c\u96e2\u4e0d\u958b\u60a3\u8005\u3001\u7814\u7a76\u8005\u8207\u7814\u767c\u5718\u968a\u7684\u5171\u540c\u52aa\u529b\u8207\u5949\u737b\uff0c\u8a72\u7814\u7a76\u7372\u5f97\u7684\u7a81\u7834\u6027\u6210\u679c\uff0c\u6709\u671b\u89e3\u6c7a\u81e8\u5e8a\u672a\u76e1\u4e4b\u9700\uff0c\u70ba\u4e2d\u570bTNBC\u60a3\u8005\u5e36\u4f86\u66f4\u512a\u7684\u6cbb\u7642\u9078\u64c7\u3002\u201d<\/p>\n\n\n\n
TORCHLIGHT\u7814\u7a76\uff08NCT04085276\uff09\u662f\u570b\u5167\u9996\u500b\u5728\u665a\u671fTNBC\u514d\u75ab\u6cbb\u7642\u9818\u57df\u53d6\u5f97\u967d\u6027\u7d50\u679c\u7684\u2162\u671f\u8a3b\u518a\u7814\u7a76<\/strong>\uff0c\u572856\u5bb6\u4e2d\u5fc3\u958b\u5c55\uff0c\u81ea2018\u5e7412\u670825\u65e5\u81f32022\u5e7411\u670830\u65e5\uff0c\u5171\u5165\u7d44531\u4f8b\u9996\u8a3a\u2163\u671f\u6216\u5fa9\u767c\u8f49\u79fb\u6027TNBC\u60a3\u8005\uff0c\u4ee52:1\u7684\u6bd4\u4f8b\u96a8\u6a5f\u63a5\u53d7\u7279\u745e\u666e\u5229\u55ae\u6297\uff08240mg, Q3W\uff09\u6216\u5b89\u6170\u5291\u806f\u5408nab-P\uff08125mg\/m2, \u7b2c1\u5929\u548c\u7b2c8\u5929, Q3W\uff09\u6cbb\u7642\uff0c\u76f4\u5230\u75be\u75c5\u9032\u5c55\u6216\u8005\u51fa\u73fe\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u7b49\u60c5\u6cc1\u767c\u751f\u3002\u6309\u7167PD-L1\u8868\u9054\u60c5\u6cc1\uff08CPS\u22651 vs. CPS<1\uff09\u3001\u65e2\u5f80\u7d2b\u6749\u985e\u85e5\u7269\u6cbb\u7642\u53f2\uff08\u662f vs. \u5426\uff09\u3001\u76ee\u524d\u6cbb\u7642\u7dda\u6578\uff08\u4e00\u7dda vs. \u4e8c\u7dda\uff09\u9032\u884c\u5206\u5c64\u3002\u4e3b\u8981\u7d42\u9ede\u70ba\u76f2\u614b\u7368\u7acb\u4e2d\u5fc3\u8a55\u5be9\u59d4\u54e1\u6703\uff08BICR\uff09\u6839\u64daRECIST v1.1\u6a19\u6e96\u8a55\u4f30\u7684PD-L1\u967d\u6027\u4eba\u7fa4\u548c\u610f\u5411\u6027\u6cbb\u7642 (ITT) \u4eba\u7fa4\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3002\u6b21\u8981\u7d42\u9ede\u5305\u62ec\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u30011\u5e74\u548c2\u5e74OS\u7387\u3001\u7814\u7a76\u8005\u8a55\u4f30\u7684PFS\u3001\u7814\u7a76\u8005\u548cBICR\u8a55\u4f30\u7684\u5ba2\u89c0\u7de9\u89e3\u7387 (ORR)\u3001\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u3001\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08DoR\uff09\u548c\u5b89\u5168\u6027\u3002<\/p>\n\n\n\n
353\u4f8b\u60a3\u8005\u96a8\u6a5f\u81f3\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408nab-P\u7d44\uff0c178\u4f8b\u60a3\u8005\u96a8\u6a5f\u81f3\u5b89\u6170\u5291\u806f\u5408nab-P\u7d44\uff0c\u5169\u7d44PD.1\u967d\u6027\u60a3\u8005\u5206\u5225\u6709200\u4f8b\u548c100\u4f8b\u3002\u7121\u8ad6ITT\u4eba\u7fa4\u548cPD-L1\u967d\u6027\u4e9e\u7d44\u4eba\u7fa4\uff0c\u5169\u7d44\u60a3\u8005\u7684\u57fa\u7dda\u4eba\u9580\u7d71\u8a08\u5b78\u548c\u75be\u75c5\u7279\u5fb5\u90fd\u5747\u8861\u3002<\/p>\n\n\n\n
\u9810\u8a2d\u7684\u671f\u4e2d\u5206\u6790\u7d50\u679c\u986f\u793a\uff1a<\/p>\n\n\n\n
\n
\u8207\u55ae\u7d14\u5316\u7642\u00a0(nab-P)\u00a0\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408nab-P\u986f\u8457\u5ef6\u9577PD-L1\u967d\u6027\u4eba\u7fa4\u7684PFS\uff08BICR\u8a55\u4f30\u7684\u4e2d\u4f4dPFS\uff1a8.4 vs. 5.6\u500b\u6708\uff09\uff0c\u5c07\u75be\u75c5\u9032\u5c55\u6216\u6b7b\u4ea1\u98a8\u96aa\u964d\u4f4e35%\u00a0(HR=0.65, 95%CI 0.470-0.906\uff09\uff0cP=0.0102\u3002\u540c\u6642\u5728ITT\u4eba\u7fa4\u4e2d\uff0cPFS\u4e5f\u6709\u76f8\u4f3c\u7684\u6539\u5584\u8da8\u52e2\u3002<\/li>\n\n\n\n
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<\/p>\n\n\n\n
\u3010\u53c3\u8003\u6587\u737b\u3011<\/h5>\n\n\n\n
1. Jiang, Z., Ouyang, Q., Sun, T. et al. Toripalimab plus nab-paclitaxel in metastatic or recurrent triple-negative breast cancer: a randomized phase 3 trial. Nat Med (2024).<\/h5>\n\n\n\n
<\/p>\n\n\n\n
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1. Jiang, Z., Ouyang, Q., Sun, T. et al. Toripalimab plus nab-paclitaxel in metastatic or recurrent triple-negative breast cancer: a randomized phase 3 trial. Nat Med (2024).<\/h5>\n\n\n\n<\/p>\n\n\n\n

1. Jiang, Z., Ouyang, Q., Sun, T. et al. Toripalimab plus nab-paclitaxel in metastatic or recurrent triple-negative breast cancer: a randomized phase 3 trial. Nat Med (2024).<\/h5>\n\n\n\n
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