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\u5317\u4eac\u6642\u95932024\u5e744\u67081\u65e5\uff0c\u541b\u5be6\u751f\u7269\uff081877.HK\uff0c688180.SH\uff09\u5ba3\u4f48\uff0c\u65e5\u672c\u85e5\u54c1\u548c\u91ab\u7642\u5668\u68b0\u7ba1\u7406\u5c40\uff08PMDA\uff09\u5df2\u65bc\u8fd1\u65e5\u540c\u610f\u516c\u53f8\u958b\u5c55\u6297BTLA\u55ae\u6297tifcemalimab\uff08\u7522\u54c1\u4ee3\u865f\uff1aTAB004\/JS004\uff09\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u4f5c\u70ba\u5c40\u9650\u671f\u5c0f\u7d30\u80de\u80ba\u764c\uff08LS-SCLC\uff09\u653e\u5316\u7642\u5f8c\u672a\u9032\u5c55\u60a3\u8005\u7684\u978f\u56fa\u6cbb\u7642\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u570b\u969b\u591a\u4e2d\u5fc3\u2162\u671f\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n\n\n\n

\u80ba\u764c\u662f\u76ee\u524d\u6211\u570b\u767c\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u5747\u6392\u540d\u9996\u4f4d\u7684\u60e1\u6027\u816b\u7624^{1<\/sup>\uff0c\u6309\u7d30\u80de\u985e\u578b\u5927\u81f4\u5206\u70ba\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u548c\u5c0f\u7d30\u80de\u80ba\u764c\uff08SCLC\uff09\u3002\u5176\u4e2d\uff0cSCLC\u662f\u80ba\u764c\u4e2d\u4fb5\u8972\u6027\u6700\u5f37\u7684\u4e9e\u578b^{2<\/sup>\uff0c\u7d04\u5360\u6240\u6709\u80ba\u764c\u75c5\u4f8b\u768415%-20%^{3<\/sup>\uff0c\u5177\u6709\u9032\u5c55\u8fc5\u901f\u3001\u65e9\u671f\u8f49\u79fb\u3001\u9810\u5f8c\u5dee\u7b49\u7279\u9ede^{4<\/sup>\u3002SCLC\u5206\u70ba\u5c40\u9650\u671f\uff08LS-SCLC\uff09\u548c\u5ee3\u6cdb\u671f\uff08ES-SCLC\uff09\uff0c\u5176\u4e2d\uff0cLS-SCLC\u7d04\u5360\u4e09\u5206\u4e4b\u4e00^{5<\/sup>\u3002\u5c0d\u65bc\u7121\u6cd5\u624b\u8853\u6216\u62d2\u7d55\u624b\u8853\u7684LS-SCLC\u60a3\u8005\uff0c\u540c\u6b65\u653e\u5316\u7642\uff08CRT\uff09\u70ba\u6a19\u6e96\u6cbb\u7642\uff08SOC\uff09\u3002\u4f46\u662f\u9019\u985e\u60a3\u8005\u5373\u4fbf\u63a5\u53d7\u6a19\u6e96\u540c\u6b65\u653e\u5316\u7642\uff0c\u9810\u5f8c\u4ecd\u8f03\u5dee\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u7d04\u70ba13.5\u500b\u6708\uff0c\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u572816-24\u500b\u6708\uff0c5\u5e74\u751f\u5b58\u7387\u50c515%-26%^{6\uff0c7<\/sup>\u3002LS-SCLC\u7684\u6cbb\u7642\u4ecd\u7136\u5b58\u5728\u5de8\u5927\u7684\u672a\u6eff\u8db3\u6cbb\u7642\u9700\u6c42\uff0c\u81e8\u5e8a\u4e9f\u9700\u63a2\u7d22\u7642\u6548\u66f4\u512a\u3001\u8010\u53d7\u6027\u826f\u597d\u7684\u65b9\u6848\u3002<\/p>\n\n\n\n}}}}}}

JUSTAR-001\u7814\u7a76\uff08NCT06095583\uff09\u662f\u7531\u541b\u5be6\u751f\u7269\u767c\u8d77\u7684\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u5168\u7403\u591a\u4e2d\u5fc3\u2162\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30tifcemalimab\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u5c0d\u6bd4\u7279\u745e\u666e\u5229\u55ae\u6297\u55ae\u85e5\u53ca\u5c0d\u6bd4\u5b89\u6170\u5291\u7528\u65bc\u540c\u6b65\u653e\u5316\u7642\u5f8c\u672a\u9032\u5c55LS-SCLC\u60a3\u8005\u7684\u978f\u56fa\u6cbb\u7642\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002\u8a72\u7814\u7a76\u70baBTLA\u9776\u9ede\u85e5\u7269\u5168\u7403\u9996\u500b\u78ba\u8b49\u6027\u7814\u7a76\uff0c\u7531\u5c71\u6771\u7b2c\u4e00\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u4e8e\u91d1\u660e\u9662\u58eb\u64d4\u4efb\u5168\u7403\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u8a08\u756b\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6b50\u6d32\u7b49\u5168\u740317\u500b\u570b\u5bb6\u548c\u5730\u5340\u7684\u8d85\u904e180\u5bb6\u7814\u7a76\u4e2d\u5fc3\u958b\u5c55\uff0c\u62db\u52df\u7d04756\u4f8b\u53d7\u8a66\u8005\u3002<\/p>\n\n\n\n

2023\u5e7411\u6708\uff0cJUSTAR-001\u7814\u7a76\u6210\u529f\u53ec\u958b\u5168\u7403\u555f\u52d5\u6703\uff0c\u6b63\u5f0f\u555f\u52d5\u8a72\u7814\u7a76\u9805\u76ee\u3002\u622a\u81f3\u76ee\u524d\uff0c\u4e2d\u570b\u5927\u9678\u3001\u4e2d\u570b\u81fa\u7063\u3001\u7f8e\u570b\u3001\u65e5\u672c\u3001\u683c\u9b6f\u5409\u4e9e\u3001\u571f\u8033\u5176\u76e3\u7ba1\u6a5f\u69cb\u5747\u5df2\u6279\u51c6\u8a72\u7814\u7a76\u7684\u958b\u5c55\uff0c\u7814\u7a76\u5df2\u5b8c\u6210\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6b50\u6d32\u4e09\u5730\u7684\u9996\u4f8b\u53d7\u8a66\u8005\u5165\u7d44\uff08FPI\uff09\u53ca\u9996\u6b21\u7d66\u85e5\uff0c\u6b63\u5728\u6301\u7e8c\u5165\u7d44\u4e2d\u3002<\/p>\n\n\n\n

\u3010\u53c3\u8003\u6587\u737b\u3011<\/h5>\n\n\n\n

1. https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/populations\/160-china-fact-sheet.pdf.<\/h5>\n\n\n\n

2. \u5f35\u723d\u7b49.\u5c0f\u7d30\u80de\u80ba\u764c\u500b\u9ad4\u5316\u6cbb\u7642\u9032\u5c55[J].\u4e2d\u570b\u816b\u7624\u81e8\u5e8a,2017,44(12):571-576.<\/h5>\n\n\n\n

3. Gaspar LE, et al. Small-cell lung cancer: prognostic factors and changing treatment over 15 years. Clin Lung Cancer. 2012 Mar;13(2):115-22.<\/h5>\n\n\n\n

4. Pesch B, et al. Cigarette smoking and lung cancer–relative risk estimates for the major histological types from a pooled analysis of case-control studies. Int J Cancer. 2012 Sep 1;131(5):1210-9.<\/h5>\n\n\n\n

5. Thatcher N, et al. Management of small-cell lung cancer. Ann Oncol. 2005;16 Suppl 2:ii235-9.<\/h5>\n\n\n\n

6. Faivre-Finn C, et al. Concurrent once-daily versus twice-daily chemoradiotherapy in patients with limited-stage small-cell lung cancer (CONVERT): an open-label, phase 3, randomised, superiority trial. Lancet Oncol. 2017 Aug;18(8):1116-1125.<\/h5>\n\n\n\n

7. Stinchcombe TE, et al. Limited-stage small cell lung cancer: current chemoradiotherapy treatment paradigms. Oncologist. 2010;15(2):187-95.<\/h5>\n\n\n\n
<\/p>\n\n\n\n

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