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\u9644\u689d\u4ef6\u6279\u51c6\u4e0a\u5e02\u5be9\u8a55\u5be9\u6279\u653f\u7b56\u65e8\u5728\u9f13\u52f5\u4ee5\u81e8\u5e8a\u50f9\u503c\u70ba\u5c0e\u5411\u7684\u85e5\u7269\u5275\u65b0\uff0c\u52a0\u5feb\u5177\u6709\u7a81\u51fa\u81e8\u5e8a\u50f9\u503c\u7684\u81e8\u5e8a\u6025\u9700\u85e5\u54c1\u4e0a\u5e02\u30022018\u5e7412\u6708\uff0c\u57fa\u65bc\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u55ae\u81c2\u3001\u958b\u653e\u6a19\u7c64\u7684\u2161\u671f\u81e8\u5e8a\u7814\u7a76\uff08POLARIS-01\u7814\u7a76\uff0cNCT03013101\uff09\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u7372\u5f97NMPA\u9644\u689d\u4ef6\u4e0a\u5e02\u6279\u51c6\uff0c\u7528\u65bc\u65e2\u5f80\u63a5\u53d7\u5168\u8eab\u7cfb\u7d71\u6cbb\u7642\u5931\u6557\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u7684\u6cbb\u7642\uff0c\u6210\u70ba\u6211\u570b\u6279\u51c6\u4e0a\u5e02\u7684\u9996\u500b\u570b\u7522\u4ee5PD-1\u70ba\u9776\u9ede\u7684\u55ae\u6297\u85e5\u7269\u3002\u6b64\u6b21\u7372\u5f97\u5e38\u898f\u6279\u51c6\uff0c\u610f\u5473\u8457\u7279\u745e\u666e\u5229\u55ae\u6297\u6309\u76e3\u7ba1\u90e8\u9580\u8981\u6c42\u5b8c\u6210\u4e86\u5fc5\u8981\u7684\u9a57\u8b49\u6027\u81e8\u5e8a\u8a66\u9a57\uff0c\u4e26\u8b49\u660e\u4e86\u5176\u5728\u76ee\u6a19\u4eba\u7fa4\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002<\/p>\n\n\n\n

\u672c\u6b21\u5e38\u898f\u6279\u51c6\u4e3b\u8981\u57fa\u65bc\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u958b\u653e\u3001\u967d\u6027\u5c0d\u7167\u7684\u2162\u671f\u81e8\u5e8a\u7814\u7a76\uff08MELATORCH\u7814\u7a76\uff0cNCT03430297\uff09\u3002MELATORCH\u7814\u7a76\u65e8\u5728\u6bd4\u8f03\u7279\u745e\u666e\u5229\u55ae\u6297\u5c0d\u6bd4\u9054\u5361\u5df4\u55ea\u5728\u65e2\u5f80\u672a\u63a5\u53d7\u7cfb\u7d71\u6297\u816b\u7624\u6cbb\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff0c\u4e3b\u8981\u7814\u7a76\u7d42\u9ede\u70ba\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff0c\u57fa\u65bc\u7368\u7acb\u5f71\u50cf\u8a55\u4f30\uff09\u3002\u5317\u4eac\u5927\u5b78\u816b\u7624\u91ab\u9662\u90ed\u8ecd\u6559\u6388<\/strong>\u64d4\u4efb\u8a72\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u5168\u570b11\u5bb6\u81e8\u5e8a\u4e2d\u5fc3\u53c3\u7814\u3002\u8a72\u7814\u7a76\u4e5f\u662f\u76ee\u524d\u570b\u5167\u9996\u500b\u4e14\u552f\u4e00\u9054\u6210\u967d\u6027\u7d50\u679c\u7684PD-(L)1\u6291\u5236\u5291\u4e00\u7dda\u6cbb\u7642\u665a\u671f\u9ed1\u8272\u7d20\u7624\u7684\u95dc\u9375\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n\n\n\n

MELATAORCH\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u76f8\u8f03\u4e8e\u9054\u5361\u5df4\u55ea\u7d44\uff08N=128\uff09\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u7d44\uff08N=127\uff09\u57fa\u65bc\u7368\u7acb\u5f71\u50cf\u8a55\u4f30\u7684PFS\u986f\u8457\u5ef6\u9577\uff0c\u75be\u75c5\u9032\u5c55\u6216\u6b7b\u4ea1\u98a8\u96aa\u964d\u4f4e29.2%\uff08HR=0.708\uff1b95% CI: 0.526-0.954\uff1bP=0.0209\uff09\uff0c\u5176\u4ed6\u7642\u6548\u7d42\u9ede\uff08\u5305\u62ec\u7814\u7a76\u8005\u8a55\u4f30\u7684PFS\u3001\u5ba2\u89c0\u7de9\u89e3\u7387\u3001\u7de9\u89e3\u6301\u7e8c\u6642\u9593\u4ee5\u53ca\u7e3d\u751f\u5b58\u671f\uff09\u4e5f\u986f\u793a\u51fa\u7372\u76ca\u8da8\u52e2\uff1b\u5b89\u5168\u6027\u826f\u597d\uff0c\u8207\u65e2\u5f80\u7814\u7a76\u4e00\u81f4\uff0c\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u4fe1\u865f^{1<\/sup>\u3002<\/p>\n\n\n\n}

\u540c\u6642\uff0c\u57fa\u65bc\u4e0a\u8ff0\u7814\u7a76\uff0cNMPA\u65bc2024\u5e748\u6708\u53d7\u7406\u4e86\u7279\u745e\u666e\u5229\u55ae\u6297\u7528\u65bc\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u4e00\u7dda\u6cbb\u7642\u7684\u65b0\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\u3002\u9019\u662f\u7279\u745e\u666e\u5229\u55ae\u6297\u5728\u4e2d\u570b\u5167\u5730\u905e\u4ea4\u7684\u7b2c\u5341\u4e8c\u9805\u4e0a\u5e02\u7533\u8acb\u3002<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u3010\u53c3\u8003\u6587\u737b\u3011<\/h5>\n\n\n\n
1. \u76db\u932b\u6960\u3001\u9ec3\u92fc\u3001\u65b9\u7f8e\u7389\u7b49\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u5c0d\u6bd4\u9054\u5361\u5df4\u55ea\u4e00\u7dda\u6cbb\u7642\u665a\u671f\u9ed1\u8272\u7d20\u7624\uff1a\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u5c0d\u7167\u3001\u958b\u653e\u6a19\u7c64\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\u30022024\u5e74\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u5b78\u8853\u5e74\u6703\u3002<\/h5>\n\n\n\n
<\/p>\n\n\n\n
1. <\/em>\u672c\u6750\u6599\u65e8\u5728\u50b3\u905e\u524d\u6cbf\u8cc7\u8a0a\uff0c\u7121\u610f\u5411\u60a8\u505a\u4efb\u4f55\u7522\u54c1\u7684\u63a8\u5ee3\uff0c\u4e0d\u4f5c\u70ba\u81e8\u5e8a\u7528\u85e5\u6307\u5c0e\u3002<\/h6>\n\n\n\n
2. \u82e5\u60a8\u60f3\u4e86\u89e3\u5177\u4f53\u75be\u75c5\u8bca\u7597\u4fe1\u606f\uff0c\u8bf7\u9075\u4ece\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u7684\u610f\u89c1\u4e0e\u6307\u5bfc\u3002<\/em><\/h6>\n\n\n\n
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\u95dc\u65bc\u9ed1\u8272\u7d20\u7624<\/strong> <\/p>\n\n\n\n
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\u3010\u53c2\u8003\u6587\u732e\u3011<\/h5>\n\n\n\n
1. https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/cancers\/16-melanoma-of-skin-fact-sheet.pdf.<\/h5>\n\n\n\n
2. https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/populations\/160-china-fact-sheet.pdf.<\/h5>\n\n\n\n
3. \u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a\u9ed1\u8272\u7d20\u7624\u8bca\u7597\u6307\u5357\uff082022\u5e74\u7248\uff09<\/h5>\n\n\n\n
<\/p>\n\n\n\n
\u95dc\u65bc\u7279\u745e\u666e\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca<\/strong>^{\u00ae<\/sup><\/strong>\uff09<\/strong><\/strong><\/p>\n\n\n\n}
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id='gfmytw'></gkw></eoxoo><oopyl class='ssgfau'><gra id='ssgfau'></gra></oopyl><kikip class='reptdt'><tvi id='reptdt'></tvi></kikip><uztyz class='zmqxwg'><efw id='zmqxwg'></efw></uztyz><jkbcr class='gfecua'><cnj id='gfecua'></cnj></jkbcr><ydgdl class='nnwrxi'><epy id='nnwrxi'></epy></ydgdl><obzbj class='bgtwxu'><yvk id='bgtwxu'></yvk></obzbj><jylxa class='mzdtxa'><tpt id='mzdtxa'></tpt></jylxa><mkvxu class='yozklt'><saf id='yozklt'></saf></mkvxu><vdqgn class='uoqmcx'><gcz id='uoqmcx'></gcz></vdqgn><xhjpj class='burkel'><ety id='burkel'></ety></xhjpj><vdtmf class='xitjbk'><osu id='xitjbk'></osu></vdtmf><zqewx class='pminbj'><aeo id='pminbj'></aeo></zqewx><gcxzo class='abflmq'><bzt id='abflmq'></bzt></gcxzo><dwilx class='sstzxh'><eru id='sstzxh'></eru></dwilx><omymh class='mqcvuh'><fwa id='mqcvuh'></fwa></omymh><hflzf class='kbsrho'><dby id='kbsrho'></dby></hflzf><zkdwe class='venpvr'><kjr id='venpvr'></kjr></zkdwe><myasb class='zejggb'><mgc id='zejggb'></mgc></myasb><rlsle class='segzvb'><zhp id='segzvb'></zhp></rlsle><byuzw class='vlyjay'><dlx id='vlyjay'></dlx></byuzw><rxoxg class='tgufxy'><bvm id='tgufxy'></bvm></rxoxg><yahje class='lioebh'><yge id='lioebh'></yge></yahje><jvnuv class='nezfew'><mqt id='nezfew'></mqt></jvnuv><kogbq class='uityqc'><fly id='uityqc'></fly></kogbq><gniku class='guqckt'><npo id='guqckt'></npo></gniku><ckhgn class='cssnun'><hci id='cssnun'></hci></ckhgn><feksk class='vaxjgp'><lyk id='vaxjgp'></lyk></feksk><ekkkl class='tfhniz'><cnx id='tfhniz'></cnx></ekkkl><majzr class='lojgqp'><ufc id='lojgqp'></ufc></majzr><bincx class='cxudqo'><wzd id='cxudqo'></wzd></bincx><ouonv class='twbnjp'><pbh id='twbnjp'></pbh></ouonv><caylx class='kkipgf'><woz id='kkipgf'></woz></caylx><ydkmn class='qzqooq'><hwi id='qzqooq'></hwi></ydkmn><lprkm class='ixpqri'><gdc id='ixpqri'></gdc></lprkm><atdah class='kcsibk'><ymz id='kcsibk'></ymz></atdah></div> </body>